The Dong Research Group

at Peking University School of Pharmaceutical Sciences

Independent research

...

Post-doctoral, graduate, and undergraduate research


13. Erythropoietin derived from chemical synthesis.

Wang, P.†; Dong, S.†(†equal contribution); Shieh, J.; Peguero, E.; Hendrickson, R.; Moore, M. A. S.; Danishefsky, S. J.* Science 2013, 342, 1357-1360. 


12. The winding pathway to erythropoietin along the chemistry-biology frontier: A success at last.
Wilson, R. M.; Dong, S.; Wang, P.; Danishefsky, S. J.* Angew. Chem.; Int. Ed. 2013, 52, 7646-7665


11. Synthesis of chamaecypanone C analogues from in situ-generated cyclopentadienones and their biological evaluation.

Dong, S.; Qin, T.; Hamel, E.; Beutler, J. A.; Porco, J. A., Jr.* J. Am. Chem. Soc. 2012, 134, 19782-19787.


10. Chemistry as an expanding resource in protein science: Fully synthetic and fully active human parathyroid hormone-related protein (1–141).

Li, J.; Dong, S.; Townsend, S. D.; Dean, T.; Gardella, T. J.; Danishefsky, S. J.*  Angew. Chem., Int. Ed. 2012, 51, 12263-12267.


9. At Last: Erythropoietin as a Single Glycoform

Wang, P.†; Dong, S.†(†equal contribution); Brailsford, J. A.; Iyer, K.; Townsend, S. D.; Zhang, Q.; Hendrickson, R.; Shieh, J.; Moore, M. A. S.; Danishefsky, S. J.* Angew. Chem., Int. Ed. 2012, 51, 11576-11584.


8.Engineering of therapeutic polypeptides through chemical synthesis: Early lessons from human parathyroid hormone and analogs.
Dong, S.
; Shang, S.; Li, J.; Tan, Z.; Maeda, A.; Dean, T.; Gardella, T. J.; Danishefsky, S. J.*  J. Am. Chem. Soc. 2012, 134, 15122-15129.


7. Advances in proline ligation.
Townsend, S. D.; Tan, Z.; Dong, S.; Shang, S.; Brailsford, J. A.; Danishefsky, S. J.* J. Am. Chem. Soc. 2012, 134, 3912-3916.


6. Toward homogeneous erythropoietin: Application of metal-free dethiylation (MFD) in the chemical synthesis of the Ala79-Arg166 glycopeptide domain.

Dong, S.; Shang, S.; Tan, Z.; Danishefsky, S. J.* Israel J. Chem. 2011, 51, 968-976.


5. An advance in proline ligation.
Shang, S.; Tan, Z.; Dong, S.; Danishefsky, S. J.* J. Am. Chem. Soc. 2011, 133, 10784-10786.


4. Microwave-assisted reaction screening: Tandem retro-Diels-Alder/Diels-Alder reaction of ortho-quinol dimers.
Dong, S.
; Cahill, K. J.; Kang, M.-I.; Colburn, N. H.; Henrich, C. C.; Wilson, J. A.; Beutler, J. A.; Johnson, R. P.; Porco, J. A., Jr.* J. Org. Chem. 2011, 76, 8944-8954.


3. Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor. 

Dong, S.; Hamel, E.; Bai, R.; Covell, D. G.; Beutler, J. A.; Porco, J. A., Jr.* Angew. Chem.; Int. Ed. 2009, 48, 1494-1497.


2. Enantioselective synthesis of bicyclo[2.2.2]-ocetenones using a copper-mediated oxidative dearomatization/[4+2] dimerization cascade.
Dong, S.
; Zhu, J.; Porco, J. A., Jr.* J. Am. Chem. Soc. 2008, 130, 2738-2739.


1. Synthesis of oxygen-containing heterocyclic compounds based on the intramolecular O–H insertion and Wolff rearrangement of α-diazocarbonyl compounds.
Liao, M.; Dong, S.; Deng, G.; Wang, J.* Tetrahedron Lett. 2006, 47, 4537-4540.